HCID 178418361, compound → HCID 178507536, compound

Participants

Reaction Steps

In a flask, is dissolved 5-(3-nitrophenyl)-1,3,4-oxadiazol-2-ol (369.90 mg; 1.79 mmol; 1.00 eq.) in MeOH (20.00 ml) under innert atmosphere. Palladium 10% on charcoal (190.03 mg; 0.18 mmol; 0.10 eq.) is added and the reaction mixture is stirred 5 minutes at RT. The mixture is then put under atmospheric pressure of hydrogen. The reaction is completed after 2 hours. The mixture is filtrated on celite and rinced with MeOH. The solvents are evaporated under vacuo, affording 5-(3-aminophenyl)-1,3,4-oxadiazol-2-ol as a white powder (283.30 mg; 89.55%). 1H NMR (DMSO-d6) δ: 5.43 (s, 2H), 6.70 (m, 1H), 6.89 (m, 1H), 7.08 (s, 1H), 7.14 (m, 1H), 12.44 (s, 1H).

Provenance & Evidence