Ethanol → HCID 86626619, compound

Participants

Reaction Steps

According to the general procedure 1, N-[3-(1,3-dioxolan-2-yl)phenyl]thiourea (prepared from 3-aminobenzyldehyde ethylene acetal (Alfa), following procedure D) is added to a solution of N-[5-(bromoacetyl)-4-methyl-1,3-thiazol-2-yl]acetamide (Intermediate 1) in EtOH. The mixture is stirred 5 hours at RT. The solvents are evaporated and the desired product is purified by crystallization. N-(2-{[3-(1,3-dioxolan-2-yl)phenyl]amino}-4′-methyl-4,5′-bi-1,3-thiazol-2′-yl)acetamide is isolated as a beige solid (320 mg; 88%). HPLC, Rt: 3.26 min (purity: 90.29%).

Provenance & Evidence