Chloroacetyl chloride → HCID 118117773, compound

Participants

Reaction Conditions

Reaction Steps

Chloroacetylchloride (1.05 mL, 13.1 mmol) was added dropwise to a 0° C. solution of (R)-2-amino-3-(3-iodo-phenyl)-propan-1-ol A-8 (3.03 g, 10.9 mmol) and Et3N (1.98 mL, 14.2 mmol) in THF (50 mL) under argon and the resulting suspension was warmed to RT and stirred for 30 min. The reaction mixture was cooled back to 0° C. before being quenched with water and concentrated in vacuo. The remaining aq. phase was extracted with EtOAc (2×) and the combined organic extracts were washed with brine, dried over Na2SO4, filtered and evaporated in vacuo to give the title compound as a cream solid that was used further without purification. LC-MS B: tR=0.71 min; [M(35Cl)+H]+=353.75.

Provenance & Evidence