Pivalaldehyde → HCID 10797610, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of DL-alanine ethyl ester hydrochloride (10 g, 65.1 mmol) in DCM (150 mL) was washed with 2M aq. NaOH and the layers were separated. The organic phase was dried over Na2SO4, filtered and the filtrate was cooled to 0° C. before MgSO4 hydrate (11.3 g) followed by pivalaldeyde (7.72 g, 89.6 mmol) were added and the resulting mixture was warmed to RT and stirred for 16 h. The reaction mixture was filtered and evaporated in vacuo to give rac-ethyl 2-((2,2-dimethylpropylidene)amino)propanoate that was used further without purification.

Provenance & Evidence