Isobutane → HCID 89560257, compound

HRID 1747236Notes

Reaction equation

HRID 1747236 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16](I)[CH:15]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH:21]1[CH:25]=[CH:24][N:23]=[N:22]1.C(C)(C)C>>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([N:22]2[N:23]=[CH:24][CH:25]=[N:21]2)[CH:15]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 6360IsobutaneHCID 89560262HCID 89560262, compoundHCID 178418936HCID 178418936, compound

Product 1

HCID 89560257HCID 89560257, compound

Procedure

(S)-2-(3-[1,2,3]Triazol-2-yl-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester was prepared from (S)-2-(3-iodo-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester and 1H-1,2,3-triazole in analogy to the procedure described for A-13. LC-MS A: tR=0.97 min; [M+H-tBu]+=273.16.

Sources & evidence

ORD record
ord-9ee4f53fee374c3f88df2f0fbdee7742
Source dataset
uspto-grants-2015_10
Patent number
US09150566B2

Reaction notes

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