HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1747256Generated: November 3, 2026
2-Propanol, reaction products with ammonia, distn. residues → Vemurafenib
https://huagongshe.com/reaction/1747256
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Propanol, reaction products with ammonia, distn. residues | HCID 18331942 | — |
| Reactant | N-(3-(5-(4-chlorophenyl)-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide | HCID 51001026 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Vemurafenib | HCID 42611257 | — |
Reaction Steps
To a high pressure vessel is added compound 9 (1.70 kg, 2.567 mol) in THF (5 L), followed by an ammonia/isopropyl alcohol solution (30.80 mol of ammonia in 12 L of isopropyl alcohol). The mixture is heated to 100° C. overnight. When the reaction is completed, the solvents are removed in vacuum and the residue is dissolved in isopropanol. Compound 10 is isolated and further purified by recrystallization using a mixture of THF (7 L) and isopropanol (14 L). Yield: 0.763 kg (60.7%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09150570B2 |
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| Source dataset | uspto-grants-2015_10 |
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| ORD ID | ord-66a8408b121e45de96f4c940aaec7e07 |
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| Source note | uspto-grants-2015_10 |
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