Hydrochloric Acid → HCID 59497244, compound

Participants

Reaction Steps

A solution of 3-[3-(5-Chloro-benzo[b]thiophen-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-propionic acid ethyl ester (50 mg, 0.12 mmol) in MeOH (3 mL) was added 2N NaOH (1 mL). The reaction mixture was stirred at room temperature for 1 h. The solution was then treated with 1M HCl solution until pH ˜4 and extracted with CH2Cl2. The organic phase was dried over Na2SO4 and concentrated. The resulting residue was purified by silica gel prep TLC using 95:5 CH2Cl2:MeOH as an eluent to afford 20 mg (42%) of the desired product as a white solid. LCMS (ESMS): m/z 387.89 (M+H+).

Provenance & Evidence