Hydrochloric Acid → HCID 59497268, compound

Participants

Reaction Steps

To a solution of (E)-3-(3-Naphthalen-1-ylmethyl-2-oxo-2,3-dihydro-benzimidazol-1-yl)-acrylic acid ethyl ester (0.1 g, 0.30 mmol) in MeOH (10 mL) was added 2N NaOH (5 mL). The reaction mixture was stirred at room temperature for 3 h. Since the mixture was heterogeneous, the mixture was heated to 60° C. for 2 h. The reaction mixture was then treated with 1N HCl and extracted with CH2Cl2. The organic phase was dried over Na2SO4 and concentrated. The resulting residue was purified by silica gel prep TLC using 10:1 CH2Cl2:MeOH as an eluent to afford 30 mg of the title compound as an off-white solid. LCMS (ESMS): m/z 345.12 (M+H+).

Provenance & Evidence