反应详情

To a solution of (S)-3-(5-Methyl-2-nitro-phenylamino)-5-phenyl-pentanoic acid ethyl ester (0.9 g, 2.5 mmol) in MeOH (20 mL) was added slurry of Pd/C (0.2 g) in MeOH. The reaction mixture was de-gassed using house vacuum. The reaction mixture was stirred under H2 balloon for 3 h. When the reaction color changed from orange to colorless, the reaction mixture was filtered through a pad of celite. The filtrate was concentrated to afford 0.84 g the desired product. This product was used for the next reaction without further purification.

1. customThe reaction mixture was de-gassed
2. filtrationwas filtered through a pad of celite
3. concentrationThe filtrate was concentrated