Hydrochloric Acid → HCID 25126219, compound

Participants

Reaction Steps

To a solution of (S)-3-[6-Methyl-3-(4-methyl-benzo[b]thiophen-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-hexanoic acid ethyl ester (0.12 g, 0.23 mmol) in MeOH (5 mL) was added 2N NaOH (2 mL). The reaction mixture was stirred at room temperature for 2 h. When the reaction was complete, the reaction mixture was treated with 1N HCl and extracted with CH2Cl2 (×2). The organic phase was dried over Na2SO4 and concentrated. The resulting residue was purified by silica gel prep TLC using 10:1 CH2Cl2:MeOH as an eluent to afford 0.1 g of the title compound as a white solid. LCMS (ESMS): m/z 485.54 (M+H+).

Provenance & Evidence