Lithium hydroxide, monohydrate → HCID 59497480, compound

Participants

Reaction Steps

To a stirred solution of 3-[3-(4-chloro-1,2,3-trimethyl-1H-indol-7-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-propionic acid methyl ester (40 mg, 0.09 mmol) in THF (3 ml) and water (1 ml) was added lithium hydroxide monohydrate (10 mg, 0.24 mmol). The resulting mixture was stirred at ambient temperature until all of the starting material was consumed. After this time the reaction was concentrated to low volume and diluted with water (10 ml) and acetic acid (0.5 ml). The resulting heterogeneous mixture was stirred at ambient temperature for 18 h. The solid product was collected via filtration and suspended in acetonitrile. The product was collected once more via filtration and washed with minimal acetonitrile to give 5 mg (13%) of the desired product. LCMS (ESMS): m/z 412.88 (M+H+).

Provenance & Evidence