Lithium Hydroxide → HCID 59497478, compound

Participants

Reaction Steps

To a solution of 7-[3-(2-Ethoxycarbonyl-ethyl)-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl]-1,2,3-trimethyl-1H-indole-6-carboxylic acid methyl ester (60 mg, 0.13 mmol) in 1,4-dioxane (5 mL) and H2O (2 mL) was added LiOH (6.4 mg). The solution was stirred at room temperature for 5 hours. The solution was concentrated and the residue was purified by CombiFlash with 10% MeOH in CH2Cl2 as the eluent to afford the desirable product 7-[3-(2-Carboxy-ethyl)-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl]-1,2,3-trimethyl-1H-indole-6-carboxylic acid methyl ester (10 mg, 17%) as a white solid. LC-MS (M+): 435.36.

Provenance & Evidence