Diisopropylethylamine → HCID 59497561, compound

Participants

Reaction Steps

3-fluoro-4-nitro-benzoic acid tert-butyl ester (1 g, 4.14 mmol) and Beta-Alanine ethyl ester hydrochloride 1.037 g, 6.75 mmol) were dissolved in DMF (10 ml). To the solution DIEA 0.872 g, 6.75 mmol) was added and the mixture stirred at room temperature overnight. The reaction mixture was diluted with water (100 ml), extracted with Ethyl acetate 3×, dried over MgSO4, filtered and evaporated to dryness to afford 1.2 g of solid was obtained (86%).

Provenance & Evidence