Lithium hydroxide, monohydrate → HCID 56670144, compound

Participants

Reaction Steps

To a stirred solution of 3-[3-(1,2-dimethyl-1H-indol-7-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-propionic acid methyl ester (90 mg, 0.24 mmol) in THF (3 ml) and water (0.5 ml) was added lithium hydroxide monohydrate (15 mg, 0.36 mmol). The reaction was stirred for 0.5 h and concentrated to low volume. The remaining residue was diluted with water and acetic acid (0.3 ml). The resulting suspension was stirred at ambient temperature over night. The precipitate was collected via filtration, washed with water and then suspended in 1:1 acetonitrile/water. The solid precipitate was isolated via filtration and dried to give 65 mg (87%) of 3-[3-(1,2-dimethyl-1H-indol-7-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-propionic acid. LCMS (ESMS): m/z 364.41 (M+H).

Provenance & Evidence