1,1'-Carbonyldiimidazole → 4-(2-Oxo-2,3-dihydro-benzimidazol-1-yl)-pentanoic acid methyl ester

Participants

Reaction Steps

To a solution of 4-(2-amino-phenylamino)-pentanoic acid methyl ester (1.05 g, 4.7 mmol) in THF (15 mL) was added 1,1′-carbonyldiimidazole (0.8 g, 4.9 mmol). The solution was stirred at room temperature for 16 hours. The reaction mixture was concentrated. The resulting residue was purified by CombiFlash with 50% EtOAc in Hexane as the eluent to afford the desired 4-(2-oxo-2,3-dihydro-benzimidazol-1-yl)-pentanoic acid methyl ester (1.1 g, 94%).

Provenance & Evidence