反应详情

温度

50 °C

To a solution of 3-[3-(1,4-dimethyl-3H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-4-methoxy-2,2-dimethyl-butyric acid methyl ester (50 mg, 0.11 mmol) in dioxane (2.5 ml) was added a solution of LiOH monohydrate (20 mg, 0.48 mmol) in H2O (2.5 mL). The solution was stirred at 50° C. for 16 hours. The reaction mixture was allowed to cool to rt and quenched with 4M HCl in dioxane (500 □L) and concentrated. The resulting residue was purified by CombiFlash with 3% MeOH in dichloromethane as the eluent to afford the desired 3-[3-(1,4-dimethyl-3H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-4-methoxy-2,2-dimethyl-butyric acid (15 mg, 31%). LCMS (ESMS): 436.12 (M+H+).

1. temperatureto cool to rt
2. customquenched with 4M HCl in dioxane (500 □L)
3. concentrationconcentrated
4. customThe resulting residue was purified by CombiFlash with 3% MeOH in dichloromethane as the eluent