Hydrochloric Acid → HCID 59497702, compound

Participants

Reaction Steps

To a solution of 3-(2-Amino-phenylamino)-4-methoxy-butyric acid methyl ester (320 mg, 1.3 mmol) in THF (5.0 mL) is added CDT (440 mg, 2.7 mmol) at room temperature. The mixture is stirred at the same temperature for 16 hours. Then 5 mL of 1.0 M HCl solution is added along with 20 mL of water. The mixture is extracted with EtOAc (3×25 mL) and the organic layers are combined, dried and concentrated to give crude product. Purification by flash column chromatography affords 205 mg (58%) of 4-Methoxy-3-(2-oxo-2,3-dihydro-benzimidazol-1-yl)-butyric acid methyl ester.

Provenance & Evidence