HCID 59497321, compound → HCID 59497365, compound

Participants

Reaction Steps

A mixture of 65 mg (0.16 mmol) of 2-{3-[(1,4-dimethyl-1H-indol-3-yl)methyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}cyclopent-1-ene-1-carboxylic acid and 30 mg of 10% Pd/C in 3 mL of methanol was stirred at room temperature under hydrogen gas atmosphere (1 atom) for 16 h. The resulting mixture was filtered through Celite and the filtrate was concentrated. The residue was purified by combiflash to give 20 mg (31%) of 2-[3-(1,4-dimethyl-1H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-cyclopentanecarboxylic acid as a white solid.

Provenance & Evidence