Lithium Hydroxide → 3-{3-[(3,8-dimethylindolizin-1-yl)methyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}hexanoic acid

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Reaction Steps

To a solution of 3-[3-(3,8-Dimethyl-indolizin-1-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-hexanoic acid ethyl ester (10 mg, 0.023 mmol) in 1,4-dioxane (5 mL) and water (1 mL) was added LiOH (1.1 mg, 0.046 mmol) at room temperature. The solution was stirred at the same temperature for 4 hours. The solution was concentrated and water was added to the residue. The solution was acidified by 12N HCl in an ice-bath. The solid that preciptate out from the solution was collected by filtration. The solid was dried under vacuum and was confirmed to be the desirable product. LCMS (ESMS): m/z 406.27 (M+H+).

Provenance & Evidence