HCID 59497564, compound → HCID 59497334, compound

Participants

Reaction Steps

To a solution of (5-Bromo-1-methyl-1H-indol-7-yl)-methanol (220 mg, 0.92 mmol) in acetone (20 mL) was added MnO2 (239 mg, 2.7 mmol) at room temperature. The mixture was stirred at the same temperature for 3 hours. The solution was filtered and the filtrate was concentrated. The residue was purified by CombiFlash with 20% EtOAc in Hexane as the eluent to afford the desirable product 5-Bromo-1-methyl-1H-indole-7-carbaldehyde (177 mg, 81%) as a white solid.

Provenance & Evidence