Lithium Hydroxide → HCID 25125216, compound

Participants

Reaction Steps

To a solution of 3-[3-(5-Bromo-1-methyl-1H-indol-7-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-hexanoic acid ethyl ester (10 mg, 0.02 mmol) in 1,4-dioxane (5 mL) and water (1 mL) was added LiOH (1 mg, 0.04 mmol) at room temperature. The solution was stirred at the same temperature for 4 hours. The solution was concentrated and water was added to the residue. The solution was acidified by 12N HCl in an ice-bath. The solid that preciptate out from the solution was collected by filtration. The solid was dried under vacuum and was confirmed to be the desirable product. LCMS (ESMS): m/z 471.17 (M+H+).

Provenance & Evidence