Hydrochloric Acid → HCID 59497528, compound

Participants

Reaction Steps

3-[3-(6-Bromo-2-oxo-2,3-dihydro-1H-indol-4-ylmethyl)-2-oxo-2,3-dihydro-benzoimidazol-1-yl]-hexanoic acid methyl ester 80 mg (0.16 mmol) is dissolved in 2.5 mL of dioxane and then lithium hydroxide (10 mg, 0.43 mmol in 1.5 mL of water) is added drop wise to the reaction mixture. The reaction is stirred at room temperature and monitored by LC/MS. Upon completion the reaction is acidified by the addition of 1N HCl, and diluted with 10 mL of water. A solid precipitated that is collected and dried to give the title compound (73 mg. 0.15 mmol 96%). LCMS (ESMS): m/z 473.1 (M+H+).

Provenance & Evidence