Hydrochloric Acid → HCID 59497426, compound

Participants

Reaction Steps

3-[3-(5-Chloro-2-oxo-2,3-dihydro-benzooxazol-7-ylmethyl)-2-oxo-2,3-dihydro-benzoimidazol-1-yl]-hexanoic acid methyl ester (40 mg 0.08 mmol) is dissolved in 750 μL of 1,4 dioxane and then lithium hydroxide (5 mg in 750 μL of water) is added to the reaction. The reaction is stirred at room temperature for 1 hour and then acidified with 1N HCl. The product is extracted with ethyl acetate 3×1 mL) and the combined organic layers are dried, filtered and evaporated in vacuo. The crude material is purified by preparative reverse phase LC to give the title compound 20 mg (0.04 mmol, 54%). LCMS (ESMS): m/z 430.8 (M+H+).

Provenance & Evidence