HCID 59497483, compound → HCID 25128174, compound

Participants

Reaction Steps

3-[3-(6-Chloro-1H-indol-4-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-hexanoic acid ethyl ester (100 mg, 0.23 mmol), prepared as described in example 72 using the appropriate reagents, was dissolved in methanol (1 mL) and treated with Amberlyst® A26 (OH— form) (1.2 g, 1.6 mmol). The resulting mixture was agitated 18 h. The mixture was filtered and the resin was washed with several portions of methanol. The product was eluted from the resin with 20% formic acid in methanol (2×2 mL). The solution was concentrated and purified by preparative HPLC using an acetonitrile/water/formic acid gradient to provide 50 mg (53%) of the title compound. LCMS (ESMS): m/z 412 (M+H).

Provenance & Evidence