Ammonium formate → HCID 59497470, compound

Participants

Reaction Steps

To a solution of 3-[3-(6-bromo-1-methyl-1H-indol-4-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-hexanoic acid (25 mg, 0.05 mmol) in methanol (2 mL) was added ammonium formate (150 mg, 2.4 mmol) and PdC 10% (5 mg). The resulting mixture was agitated for 60 h, filtered and concentrated. The resulting residue was dispersed in DCM (2 mL), filtered, and the filtrate was washed with DCM (1×2 mL). The mother liquors were concentrated and the residue was purified by preparative HPLC using an acetonitrile/water/formic acid gradient to provide 7 mg (35%) of the title compound. LCMS (ESMS): m/z 408 (M+H).

Provenance & Evidence