HCID 178452636, compound → HCID 178452635, compound

Participants

Reaction Steps

10% palladium-carbon (M type, wet product, 2.50 g) was added to a solution of benzyl 4-{5-[(tert-butoxycarbonyl)amino]-1H-pyrazol-3-yl}piperidine-1-carboxylate (12.25 g, 30.59 mmol) produced in Reference Example 28 in methanol (130 mL), and the mixture was stirred at room temperature for 8 hours under a hydrogen atmosphere. The catalyst in the reaction solution was filtered off, and the solvent in the obtained filtrate was distilled off under reduced pressure to obtain the title compound (8.50 g).

Provenance & Evidence