Dichloromethane → HCID 178516599, compound

Participants

Reaction Steps

N,N-Diisopropylethylamine (9.37 mL, 55.1 mmol) was added dropwise at 0° C. to a solution of 4-hydroxy-3-(piperidin-4-yl)-4-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one trifluoroacetate (19.2 g, 45.9 mmol) produced in Reference Example 115 in ethanol (200 mL), and the mixture was stirred for 30 minutes. Dichloromethane (600 mL) was added thereto, and the mixture was stirred for 1 hour. Then, the precipitate was collected by filtration and dried under reduced pressure to obtain the title compound (12.6 g, yield: 91%).

Provenance & Evidence