2,3-Dichloroquinoxaline → HCID 86678190, compound

Participants

Reaction Conditions

Reaction Steps

In THF (5.0 mL) were dissolved (1-methylcyclopropyl)(pyridin-3-yl)methanol (130 mg, 0.796 mmol) obtained in Step 2 and 2,3-dichloroquinoxaline (190 mg, 0.956 mmol). To the mixture was added 60% sodium hydride (in oil, 38.2 mg, 0.956 mmol) and the mixture was stirred at 50° C. for 1.5 hours. A saturated aqueous ammonium chloride solution and water were added to the reaction mixture. Extraction with ethyl acetate, washing with saturated brine and drying over anhydrous sodium sulfate were performed. After filtration, the solvent in the filtrate was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=17/3) to give Compound A9 (147 mg, 57% yield).

Provenance & Evidence