Hydrochloric Acid → HCID 86678200, compound

Participants

Reaction Steps

In THF (6.5 mL) was dissolved 5-(diethoxymethyl)-2-(2-methyl-2H-1,2,3-triazol-4 yl)pyridine (672 mg, 2.56 mmol) obtained in Step 5. To the solution was added 1 mol/L hydrochloric acid (6.40 mL, 6.40 mmol) and the mixture was stirred at room temperature for 2 hours. A saturated aqueous sodium bicarbonate solution was added to the reaction mixture. Extraction with ethyl acetate, washing with saturated brine and drying over anhydrous sodium sulfate were performed. After filtration, the solvent in the filtrate was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate 7/3) to give 6-(2-methyl-2H-1,2,3-triazol-4-yl)nicotinaldehyde (473 mg, 98% yield).

Provenance & Evidence