反应详情

温度

90 °C

A mixture of 2-[(4aS,6R,7aS)-2-(4-methoxyphenyl)-hexahydrocyclopenta[d][1,3]dioxin-6-yl]-1H-isoindole-1,3(2H)-dione (390. mg, 1.03 mmol), EtOH (11.3 mL) and hydrazine (0.0362 mL, 1.13 mmol) was stirred at 90° C. for 18 h. The resulting mixture was purified via silica gel chromatography eluting with a gradient of 10 to 50% MeOH in DCM. LC/MS: Rt=1.08 min, ES+ 250. (AA standard).

1. customThe resulting mixture was purified via silica gel chromatography
2. washeluting with a gradient of 10 to 50% MeOH in DCM