HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Butanol → n4-Benzyl-6-chloropyrimidine-4,5-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Butanol | HCID 263 | — |
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-Amino-4,6-dichloropyrimidine | HCID 79434 | — |
| Product | n4-Benzyl-6-chloropyrimidine-4,5-diamine | HCID 258596 | 96.1% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
To a solution of 5-amino-4,6-dichloropyrimidine (8.4 g, 0.051 mol) in 1-butanol (50.0 mL, 0.547 mol) was added triethylamine (12 mL, 0.084 mol) and benzylamine (17 mL, 0.15 mol), and the mixture was heated at 100° C. for 3 hours. The reaction was cooled at 0 C, filtered and washed with ethanol. The residue was dissolved in CH2Cl2 and washed with saturated aqueous NaHCO3, and concentrated. The residue was triturated in diethyl ether to obtain 11.5 g (96%) of a light brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150525B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-5ccd05c1d87a43dba413d15c7a2d8607 |
| Source note | uspto-grants-2015_10 |