Benzoyl chloride → HCID 12611968, compound

HRID 1747692Notes

Reaction equation

HRID 1747692 reaction equation
[NH2:1][C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[N:6][C:7]=1[Cl:8].[C:10](Cl)(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[Cl:9][C:3]1[C:2]([NH:1][C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:7]([Cl:8])[N:6]=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 794345-Amino-4,6-dichloropyrimidine

Product 1

HCID 12611968HCID 12611968, compound

Conditions

Temperature
100 °C

Procedure

A mixture of 5-amino-4,6-dichloropyrimidine (1.15 g, 0.00701 mol) and benzoyl chloride (1.0 mL, 0.0086 mol) was heated at 100° C. overnight. The reaction was cooled and the residue was triturated with diethyl ether, filtered and collected to obtain 1.6 g (85%).

Workup

  1. temperatureThe reaction was cooled
  2. customthe residue was triturated with diethyl ether
  3. filtrationfiltered
  4. customcollected
  5. customto obtain 1.6 g (85%)

Sources & evidence

ORD record
ord-58b59d2969bc4c1b99cfcf702f1956a6
Source dataset
uspto-grants-2015_10
Patent number
US09150525B2

Reaction notes

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