Benzoyl chloride → 7-chloro-2-phenyl[1,3]oxazolo[5,4-d]pyrimidine

Participants

Reaction Steps

A mixture of 5-amino-4,6-dichloropyrimidine (1.05 g, 0.00640 mol) and benzoyl chloride (0.89 mL, 0.0077 mol) was subjected to microwave irradiation (100° C.) for 2 hours. The reaction was cooled and the residue was triturated with diethyl ether, filtered and collected to obtain 1.15 g (77.5%) of a yellow solid. LC/MS: Rt=1.84 min, ES+ 232.19 (AA standard).

Provenance & Evidence