Ethyl Acetate → HCID 70674227, compound

Participants

Reaction Steps

100 mg (0.4 mmol) of 7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carbonitrile (Example 6A) and 60 mg (0.71 mmol) of 1-cyanoguanidine in 1.3 ml of DMSO were stirred with 4.8 mg (0.12 mmol) of sodium hydroxide at 150° C. in a microwave reactor for 40 minutes. At 20° C., the reaction mixture was then diluted with ethyl acetate (50 ml) and washed twice with in each case 20 ml of water. Purification by HPLC (acetonitrile:water (+0.1% formic acid) gradient) and concentration of the product-containing fractions gave 37.2 mg (25% of theory) of the target compound.

Provenance & Evidence