Isopropyl chloroformate → HCID 70674231, compound

Participants

Reaction Steps

At 0° C., twice at an interval of 10 minutes, in each case 76.4 mg (0.62 mmol) of isopropyl chloroformate were added to 247 mg (0.62 mmol) of 2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidine-4,5,6-triamine (Example 9A) in 4.9 ml of pyridine. The reaction mixture was concentrated and the residue was purified by preparative HPLC (acetonitrile:water (+0.1% formic acid) gradient). This gave 189 mg (63% of theory) of the target compound.

Provenance & Evidence