Cyclopentyl chloroformate → HCID 70674345, compound

Participants

Reaction Steps

At 0° C., 37.5 mg (0.25 mmol) of cyclopentyl chlorocarbonate were added to 100 mg (0.25 mmol) of 2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidine-4,5,6-triamine (Example 9A) in 2 ml of pyridine. The reaction mixture was concentrated and the residue was purified by preparative HPLC (acetonitrile:water (+0.1% formic acid) gradient). This gave 41 mg (32% of theory) of the target compound.

Provenance & Evidence