Methyl iodide → HCID 70674573, compound

Participants

Reaction Conditions

Reaction Steps

At 0° C., 50 mg (0.11 mmol) of N-{4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}propanamide formate were initially charged in THF (0.47 ml), and 22.3 mg of a 2 N solution of sodium bis(trimethylsilyl)amide in THF (0.12 mmol) were added. After 30 min at 0° C., 14 μl (0.22 mmol) of methyl iodide were added and the mixture was stirred at 20° C. for 20 hours. The mixture was then concentrated and the residue was purified by preparative HPLC (acetonitrile/water (+0.1% formic acid) gradient). This gave 17 mg of the target compound (32% of theory).

Provenance & Evidence