Benzyl isocyanate → HCID 89615931, compound

Participants

Reaction Steps

A mixture of 3-(3-benzyloxyphenyl)-3-methyl-4,5,6,7-tetrahydrofuro[3,4-c]pyridin-1(3H)-one (50 mg, 0.15 mmol) and benzyl isocyanate (27 μL, 0.22 mmol) in dichloromethane (5 mL) was stirred at room temperature for 1 h. The solvent was removed and the resulting residue was purified on silica to give the desired product (43 mg, 61.6%). 1H NMR (300 Hz, CDCl3) δ 1.84 (s, 3H), 2.38 (br s, 2H), 3.26-3.32 (m, 1H), 3.51-3.58 (m, 1H), 3.79 (d, J=18.0, 1H), 4.37-4.30 (m, 3H), 4.94 (t, J=6.0, 1H), 5.04 (s, 2H), 6.87-6.94 (m, 3H), 7.24-7.39 (m, 11H).

Provenance & Evidence