Benzyl isocyanate → HCID 89615792, compound

Participants

Reaction Steps

A mixture of 3-(3-hydroxyphenyl)-3-methyl-4,5,6,7-tetrahydrofuro[3,4-c]pyridin-1(3H)-one (75 mg, 0.31 mmol) and benzyl isocyanate (48 μL, 0.40 mmol) in dichloromethane (5 mL) was stirred at room temperature for 1 h. The solvent was removed and the resulting residue was purified on silica to give the desired product (68 mg, 58.8%). 1H NMR (300 Hz, CDCl3) δ 1.82 (s, 3H), 2.39 (br s, 2H), 3.30-3.40 (m, 1H), 3.42-3.55 (m, 1H), 3.94 (d, J=18.0, 1H), 4.25-4.40 (m, 3H), 4.97 (t, J=6.0, 1H), 6.77-6.84 (m, 2H), 7.15-7.38 (m, 7H).

Provenance & Evidence