Benzyl isocyanate → HCID 89615896, compound

Participants

Reaction Steps

A mixture of 3-(3-chlorophenyl)-3-isobutyl-4,5,6,7-tetrahydrofuro[3,4-c]pyridin-1(3H)-one (70 mg, 0.23 mmol) and benzyl isocyanate (42 μL, 0.34 mmol) in dichloromethane (5 mL) was stirred at room temperature for 1 h. The solvent was removed and the resulting residue was purified on silica to give the desired product (105 mg, 100%). 1H NMR (300 Hz, CDCl3) δ 0.85 (d, J=6.0, 3H), 0.93 (d, J=6.0, 3H), 1.55-1.70 (m, 1H), 1.72-1.82 (m, 1H), 2.20-2.40 (m, 3H), 3.15-3.29 (m, 1H), 3.49-3.61 (m, 1H), 3.89 (d, J=18.0, 1H), 4.39 (d, J=3.0, 2H), 4.48 (d, J=18.0, 1H), 5.22 (t, J=6.0, 1H), 7.14-7.38 (m, 9H).

Provenance & Evidence