Benzyl isocyanate → HCID 89615921, compound

Participants

Reaction Steps

Benzyl isocyanate (0.02 g, 0.14 mmol) was added to a solution of 3-phenyl-3-butyl-4,5,6,7-tetrahydrofuro[3,4-c]pyridin-1(3H)-one (0.025 g, 0.09 mmol prepared in a manner analogous to compound 2) in dichloromethane (5 mL) and was stirred at room temperature for 1 h. The solvent was removed and the resulting residue was purified on silica to give the desired product (0.018 g, 50%). 1H NMR (300 MHz, CHLOROFORM-d) δ ppm 0.79 (t, J=7.16 Hz, 3H), 1.06-1.33 (m, 4H), 1.83-1.97 (m, 1H), 2.14-2.43 (m, 3H), 3.18-3.31 (m, 1H), 3.36-3.51 (m, 1H), 3.85 (dt, J=18.84, 2.64 Hz, 1H), 4.26-4.39 (m, 3H), 4.90 (t, J=5.27 Hz, 1H), 7.11-7.36 (m, 10H).

Provenance & Evidence