Benzyl isocyanate → HCID 89615848, compound

Participants

Reaction Steps

Benzyl isocyanate (0.02 6 g, 0.2 mmol) was added to a solution of 3-phenyl-3-benzyl-4,5,6,7-tetrahydrofuro[3,4-c]pyridin-1(3H)-one (0.05 g, 0.16 mmol prepared in a manner analogous to compound 2) in dichloromethane (5 mL) and was stirred at room temperature for 1 h. The solvent was removed and the resulting residue was purified on silica to give the desired product (0.036 g, 50%). 1H NMR (300 MHz, CHLOROFORM-d) δ ppm 1.93-2.08 (m, 1H), 2.11-2.23 (m, 1H), 3.11-3.35 (m, 2H), 3.39-3.49 (m, 1H), 3.52-3.62 (m, 1H), 3.97-4.08 (m, 1H), 4.42 (dd, J=5.27, 2.64 Hz, 2H), 4.59 (dt, J=19.12, 2.12 Hz, 1H), 4.90 (t, J=5.46 Hz, 1H), 7.15-7.47 (m, 15H).

Provenance & Evidence