Benzyl isocyanate → HCID 89615887, compound

Participants

Reaction Steps

Benzyl isocyanate (0.069 g, 0.52 mmol) was added to a solution of 3-phenyl-3-hydroxymethyl-4,5,6,7-tetrahydrofuro[3,4-c]pyridin-1(3H)-one (0.128 g, 0.52 mmol prepared in a manner analogous to compound 2) in dichloromethane (10 mL) and was stirred at room temperature for 1 h. The solvent was removed and the resulting residue was purified on silica to give the desired product (0.101 g, 51%). 1H NMR (300 MHz, CHLOROFORM-d) δ ppm 2.18-2.47 (m, 2H), 3.19-3.31 (m, 1H), 3.63 (dt, J=13.75, 4.99 Hz, 1H), 3.94-4.07 (m, 3H), 4.07-4.18 (m, 1H), 4.35 (d, J=5.65 Hz, 2H), 4.47 (d, J=18.84 Hz, 1H), 5.50 (t, J=5.65 Hz, 1H), 7.15-7.25 (m, 4H), 7.27-7.42 (m, 6H).

Provenance & Evidence