Benzyl isocyanate → HCID 89615756, compound

Participants

Reaction Steps

Benzyl isocyanate (0.02 g, 0.15 mmol) was added to a solution of 3-phenyl-3-neopentyl-4,5,6,7-tetrahydrofuro[3,4-c]pyridin-1(3H)-one (0.043 g, 0.15 mmol prepared in a manner analogous to compound 2) in dichloromethane (10 mL) and was stirred at room temperature for 1 h. The solvent was removed and the resulting residue was purified on silica to give the desired product (0.041 g, 63%). 1H NMR (300 MHz, CHLOROFORM-d) δ ppm 0.87 (s, 9H), 1.88 (d, J=14.88 Hz, 1H), 2.28-2.43 (m, 2H), 2.38 (d, J=14.88 Hz, 1H), 3.16-3.28 (m, 1H), 3.53 (s, 1H), 3.96 (dt, J=19.03, 2.50 Hz, 1H), 4.42 (d, J=5.65 Hz, 2H), 4.59 (s, 1H), 4.88-4.99 (m, 1H), 7.20-7.41 (m, 10H).

Provenance & Evidence