HCID 89586219, compound → HCID 89586288, compound

Participants

Reaction Steps

A suspension of 3-acetyl-1-[3-(trifluoromethyl)phenyl]furo[3,2-c]pyridazin-4(1H)-one (806 mg) and 10% palladium on carbon (containing water (50%), 400% mg) in methanol (25 mL) was stirred at room temperature for 24 hr under a hydrogen atmosphere. Palladium on carbon was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate) and crystallized from hexane/ethyl acetate to give the title compound (686 mg).

Provenance & Evidence