Sodium Hydroxide → HCID 89586468, compound

Participants

Reaction Steps

To a solution of 3-(1-hydroxyethyl)-1-[3-(trifluoromethyl)phenyl]-6,7-dihydrofuro[3,2-c]pyridazin-4(1H)-one (0.858 g) in acetonitrile (20 mL) was added Dess-Martin Periodinane (1.23 g) portionwise, and the mixture was stirred at room temperature for 1 hr. The reaction mixture was poured into 1M aqueous sodium hydroxide solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/methanol) and recrystallized from ethyl acetate to give the title compound (0.739 g).

Provenance & Evidence