Water → HCID 68014809, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 1-[4-iodo-3-(trifluoromethoxy)phenyl]-3-(1-phenyl-1H-pyrazol-5-yl)furo[3,2-c]pyridazin-4(1H)-one (300 mg), pyrazole (72 mg), copper oxide(I) (7.6 mg), 2-hydroxybenzaldehydeoxime (29 mg) and cesium carbonate (346 mg) in DMF (5 mL) was stirred at 50° C. for 12 hr, and water was added. The reaction mixture was extracted with ethyl acetate, the extract was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (methanol/ethyl acetate) to give the title compound (25 mg).

Provenance & Evidence