Acetic Acid → 4-Chloro-6-phenylpyridazin-3(2H)-one

HRID 1747784Notes

Reaction equation

HRID 1747784 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][C:7]=1[Cl:8].C(O)(=[O:17])C>>[Cl:8][C:7]1[C:2](=[O:17])[NH:3][N:4]=[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 131632313,4-Dichloro-6-phenylpyridazine

Product 1

HCID 131632454-Chloro-6-phenylpyridazin-3(2H)-one

Procedure

A mixture of 3,4-dichloro-6-phenylpyridazine (0.53 g) and acetic acid (2.6 mL) was heated under reflux for 5 hr, and the solvent was evaporated under reduced pressure. The residue was neutralized with saturated aqueous sodium hydrogen carbonate solution. The obtained solid was collected by filtration and recrystallized from ethanol to give the title compound (0.20 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hr
  3. customthe solvent was evaporated under reduced pressure
  4. filtrationThe obtained solid was collected by filtration
  5. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-7b8cf674cc1743168ba9ddcb49fb8d25
Source dataset
uspto-grants-2015_10
Patent number
US09150588B2

Reaction notes

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