HCID 89586211, compound → HCID 89586364, compound

Participants

Reaction Steps

3-Bromo-5-methoxy-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one (0.800 g) and palladium on carbon (0.24 g, palladium 10%, 50% water moistened product) were suspended in THF (14 mL), and the suspension was stirred at room temperature for 2.5 days under a hydrogen atmosphere. The reaction mixture was filtered through celite, and the filtrate was concentrated and purified by silica gel column chromatography (ethyl acetate/hexane→methanol/ethyl acetate) to give the title compound (0.185 g).

Provenance & Evidence