Sodium Iodide → HCID 89586036, compound

Participants

Reaction Steps

To a solution of sodium iodide (0.513 g) in acetonitrile (4 mL) was added chlorotrimethylsilane (0.434 mL) at room temperature. The reaction mixture was stirred at room temperature for 30 min, a solution of 5-methoxy-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one (0.185 g) in acetonitrile (6 mL) was added at room temperature. The reaction mixture was heated under reflux for 3 hr, cooled to room temperature, diluted with water, extracted with ethyl acetate, washed with saturated brine, dried over anhydrous sodium sulfate, filtered, concentrated, and purified by silica gel column chromatography (ethyl acetate/hexane-methanol/ethyl acetate) to give the title compound (0.317 g).

Provenance & Evidence